spontaneous intracerebral hemorrhage
Conditions
Interventions
Minimally invasive puncture combined with urokinase group:Minimally invasive puncture combined with urokinase
Standard drug treatment group:Standard drug treatment
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Diagnosis of cerebral hemorrhage by CT scan of the head; 3. Calculate the volume of hemorrhagic swell >= 10ml based on the head CT examination; 4. Within 14 days of onset; 5. GCS score 4-14 points before entering the group; 6. Before the onset of mRS 0-1 points.
Exclusion criteria
Exclusion criteria: 1. Combined with aneurysms, arteriovenous malformations, brain trauma, brain tumors, large-area cerebral infarction, ß amyloidosis, severe coagulation dysfunction; 2. Patients with intraventricular hemorrhage or ICH breaking into the ventricle; 3. Any history of brain parenchymal or other intracranial subarachnoid, subdural or epidural hemorrhage and surgical history within the past 30 days; 4. Patients with coagulation dysfunction such as genetics or acquired hemorrhagic constitution, lack of coagulation factors; 5. Hemoglobin1.4; 7. It is expected that long-term anticoagulation and antiplatelet therapy will be needed; 8. Past history of internal hemorrhage, such as gastrointestinal bleeding, urogenital bleeding, and respiratory tract bleeding that is not completely controlled; 9. Myocardial infarction in the past 30 days; 10. Known to have a high risk of embolism, including patients with implanted mechanical heart valves, a history of left heart thrombosis, mitral valve stenosis with atrial fibrillation, acute pericarditis or subacute bacterial endocarditis. Atrial fibrillation without mitral stenosis is suitable; 11. Severe liver damage, ALT>3 times the upper limit of normal, or AST>3 times the upper limit of normal. Severe renal insufficiency, glomerular filtration rate <30ml/min/1.73m2; 12. Patients suffering from Alzheimer's disease or mental illness cannot complete the follow-up plan as required; 13. Combine any serious diseases that may interfere with the test results after evaluation: including diseases such as respiratory system, circulatory system, digestive system, genitourinary system, endocrine system, immune system and blood system; 14. People who currently abuse or rely on drugs or alcohol are expected to have poor compliance and difficult to complete the follow-up; 15. Allergic to urokinase or surgery-related drugs and devices; 16. Women who are pregnant or breastfeeding, or who plan to become pregnant within one year.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mRS score; | — |
Countries
China
Contacts
Public ContactYang Qingwu
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed