Pheochromocytoma and paraganglioma
Conditions
Interventions
Intervention Group:Magnesium sulphate
Control Group:0.9% saline
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Clinically diagnosed as resectable pheochromocytoma or paraganglioma that may be resected, elective surgical resection is planned; 3. Before operation, prepare for operation with a-receptor blocker, and the medication time is more than 7 days; 4. Preoperative preparation is sufficient, blood pressure is controlled below 140/90mmHg, and heart rate is controlled below 90 beats/min.
Exclusion criteria
Exclusion criteria: 1. Severe liver dysfunction (Child-Pugh grade C) or renal failure (requires renal replacement therapy) before surgery; 2. Allergic to study drugs; 3. There is hypermagnesemia before the operation; 4. The attending doctor or researcher believes that there are other situations that are not suitable for participating in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative hemodynamic instability; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total amount of phentolamine, esmolol and catecholamine infusions during surgery;Blood catecholamine concentration measured during surgery;Proportion of prolonged hypotension after surgery;Complications within 30 days after surgery;Maximum SBP;Minimum MAP;Maximum HR; | — |
Countries
China
Contacts
Public ContactKong Hao
Peking University First Hospital
Outcome results
None listed