Chronic lymphocytic leukemia, CLL
Conditions
Interventions
case series:Nil
Sponsors
Jiangsu Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Aged >=18 years; 2.Diagnosis of CLL that meets the?2016?World Health Organization?(WHO) classification system?for?tumors?of the?hematopoietic?and lymphoid tissues; 3.No previous treatment; 4.Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, or 2; 5.Signed informed consent in keeping with the policies of the hospital.
Exclusion criteria
Exclusion criteria: 1. History of other malignant tumors, except for carcinoma in situ or malignant tumors that can be cured; 2. Active or difficult to control infections such as patients with hepatitis B, hepatitis C or HIV infection; 3. Autoimmune diseases and immunodeficiencies that are difficult to control; 4. Pregnant women and lactating women, female patients of childbearing age must test negative within 7 days before enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The sensitivity of MRD detection by NGS and FCM that allows risk stratification?of the CLL patients;Median overall survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of participants with overall?MRD negative status;Percentage of participants with detectable MRD by FCM but without detectable MRD by NGS;Median progression free survival; | — |
Countries
China
Contacts
Public ContactLi Jianyong
Jiangsu Provincial People's Hospital
Outcome results
None listed