Gastrointestinal diseases
Conditions
Interventions
The control group:One day before surgery, 411.45g of compound PEG electrolyte was taken orally
Experimental group:Compound polyethylene glycol 274.3g was taken orally 2 days before surgery, and compound polyethylene glycol electrolyte 137.15g was taken orally 1 day before surgery
Sponsors
Shandong First Medical University Affiliated Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years, male or non-pregnant female; 2. American Association of Anesthesiologists ASA Class I-III; 3. According to the preoperative colonoscopy biopsy pathological results, it is confirmed to be rectal adenocarcinoma or high-grade intraepithelial neoplasia; 4. The tumor is located in the rectum; 5. The surgical method is determined to be low rectal anterior resection; 6.Patients who agree to receive adjuvant treatment in accordance with the standard; 7. The patient or family members can understand the purpose of the trial, voluntarily participate in and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. There is distant metastasis, the tumor invades the surrounding organs and requires joint resection of the organs or cannot achieve R0 resection; 2. Past history of malignant tumors or history of bowel surgery; 3. Patients with intestinal obstruction, intestinal perforation, intestinal bleeding, etc. who need emergency surgery; 4. Those who have taken intestinal laxative drugs for a long time; 5. Patients with inflammatory bowel disease, constipation, and irritable bowel syndrome; 6. Those who are allergic to polyethylene glycol electrolyte laxatives; 7. Severe cardiopulmonary disease, long-term use of large amounts of hormones; 8. Those who have taken antibiotics continuously for more than three days within a week before surgery; 9. Those who have participated in other clinical research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of anastomotic leakage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Infection of incision;Anal tube carrying time;Time of first fluid intake;Application of antidiarrheal drugs after operation;The hospitalization time;albumin;Pre-albumin;infection;Anal canal drainage; | — |
Countries
China
Contacts
Public ContactChen Yuezhi
Shandong First Medical University Affiliated Provincial Hospital
Outcome results
None listed