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The Efficacy of Combining Excision With 5-Fluorouracil and Glucocorticoid for the Treatment of Keloids: a Randomized Controlled Trial

The Efficacy of Combining Excision With 5-Fluorouracil and Glucocorticoid for the Treatment of Keloids: a Randomized Controlled Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100046025
Enrollment
Unknown
Registered
2021-05-02
Start date
2021-05-10
Completion date
Unknown
Last updated
2021-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keloids

Interventions

Therapy group:Surgery combined with 5-fluorouracil and glucocorticoid injection
Control group 1:5-Fluorouracil and glucocorticoid injection
Control group 2:Surgery combined with radiotherapy

Sponsors

The Second Affiliated Hospital of Xi'an Jiaotong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-60 years; 2. Meet the diagnostic criteria for keloids; 3. Have not received any relevant treatment within 3 months; 4. Blood and urine routine and biochemical set are normal; 5. Voluntary and able to cooperate with follow-up; 6. The skin lesions are in a stable period and have not progressed within 3 months (increased area, itching, pain).

Exclusion criteria

Exclusion criteria: 1. Pregnancy and lactation; 2. Patients with serious medical diseases, endocrine system diseases or tumors; 3. Patients who are allergic to glucocorticoids and 5-fluorouracil; 4. Ear keloids; 5. Accompanied by mental illness.

Design outcomes

Primary

MeasureTime frame
The Vancouver scar scale;The patientand observer scar assessment scale;—

Countries

China

Contacts

Public ContactWang Hao

The Second Affiliated Hospital of Xi'an Jiaotong University

wanghaonxyc@xjtu.edu.cn+86 18291839156

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 12, 2026