hip fractures
Conditions
Interventions
Group A:NS 100ml i.v. q12h, before surgery
1.5g TXA i.v. q12h, the first 3 days following surgery.
Group B:1.5g TXA i.v. q12h, before surgery
Sponsors
The First Affiliated Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Aged over 65 years; 2.Diagnosed with a primary, unilateral, recent hip fracture (femoral neck fracture or intertrochanteric fracture) by X-ray or CT scan; 3.Receiving hemi- or total hip arthroplasty.
Exclusion criteria
Exclusion criteria: 1. Cognitive dysfunction, inability to obtain informed consent, or rejection of participants; 2. Multiple fractures or open fractures; 3. Active bleeding (such as active gastrointestinal bleeding, cerebral hemorrhage, etc.); 4. Systemic thromboembolism (deep vein thrombosis, pulmonary embolism, etc.); 5. Coagulation dysfunction; 6. Severe neuromuscular disease; 7. Allergic to tranexamic acid.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total blood loss;Hidden blood loss;Dominant blood loss;Decline of hemoglobin;Allogeneic blood transfusion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammatory factor (ESR, CRP, PCT, IL-6, IL-8, IL-10, TNF-a);Coagulation and fibrinolysis indicators (PT, PTR, INR, PTA, APTT, TT, Fbg, FDP, D-D);Coagulation factors (II, V, VII, VIII, IX, X, XI, XII);Thromboelastogram(TEG);Time from fracture occurrence to surgery;Time form admittance to surgery;Wound complications (exudation, hematoma, infection);Length of stay;90-day mortality;Incidence of venous thromboembolism (DVT, PE);Hospitalization expenses; | — |
Countries
China
Contacts
Public ContactHuang Wei
The First Affiliated Hospital of Chongqing Medical University
Outcome results
None listed