Severe Pneumonia
Conditions
Interventions
Group A:Remazolam sedation
Group B:Midazolam sedation
Group C:Propofol sedation
Sponsors
The Affiliated Hospital of Guizhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for severe pneumonia (IDSA/ATS diagnostic criteria); 2. Aged > 18 years; 3. Required invasive mechanical ventilation.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. Chronic moderate to severe renal dysfunction (Scr > 178umol/l, urea nitrogen > 9mmol/l) and liver function abnormalities (Child-Pugh C); 3. Patients with pre-existing dementia or obvious stroke sequelae, and patients with craniocerebral trauma that cannot be assessed; 4. Allergic to opioids and benzodiazepines; 5. Long-term use of benzodiazepines; 6. Severe circulatory instability when transferred to ICU, requiring high-dose vasopressor maintenance; 7. Post-cardiopulmonary resuscitation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sedation compliance rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation time;tracheal intubation time;Vital signs(blood pressure, heart rate, respiration);liver function;kidney function;Dosage of sedative and analgesic drugs;Incidence of delirium; | — |
Countries
China
Contacts
Public ContactCheng Yumei
The Affiliated Hospital of Guizhou Medical University
Outcome results
None listed