High-grade squamous intraepithelial lesion
Conditions
Interventions
Treatment group:Xixiai
Sponsors
The Second Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntary participation in the study, and has signed the informed consent.; 2. Aged >=18 years(including the cut-off value) with sexual life history; 3. HPV were positive by HPV test (Kaipu) ; 4. The histopathology of cervical biopsy was HSIL and received cervical conization (including cold knife conization and LEEP); 5. Postoperative histopathology was negative margins; 6. Had not received anti-HPV system treatment after cervical conization; 7. Agree to take contraceptive measures before the 12th month visit after completion of treatment.
Exclusion criteria
Exclusion criteria: 1. Histopathology suggested cervical cancer; 2. Have had other uncured malignant tumors in the past 5 years or at the same time; 3. During pregnancy or lactation; 4. Suffering from severe pelvic inflammation, severe cervicitis, bleeding disease or other uncontrolled diseases; 5. Childbirth or miscarriage occurred within 6 weeks before enrollment; 6. Patients with severe heart, lung, liver and kidney diseases; 7. Suffering from severe autoimmune diseases, such as AIDS, systemic lupus erythematosus, ankylosing spondylitis, Sjogrens syndrome, rheumatoid arthritis, Hashimotos thyroiditis, etc.; 8. Have used corticosteroids, immune preparations, immunomodulators or other drugs that act on the immune system within 12 weeks; 9. Long-term oral contraceptives; 10. Allergic to egg yolks or research drugs; 11. The patient has active infection and fever of unknown origin within 7 days before randomization >= 38.5?; 12. Accompanied by epilepsy or other mental illnesses.
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Adverse Event, AE; | — |
Primary
| Measure | Time frame |
|---|---|
| HPV response rate; | — |
Countries
China
Contacts
Public ContactXu Zhen
The Second Affiliated Hospital of Zhengzhou University
Outcome results
None listed