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Effect of Heme Oxygenase-1 promoter polymorphisms on post-stroke cognitive impairment and its underlying mechanism

Case-contro study on relationship between HO-1 promoter polymophirism and post-stroke cognitive impairment in non-disabling ischemic stroke paitents

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100045869
Enrollment
Unknown
Registered
2021-04-25
Start date
2021-06-15
Completion date
Unknown
Last updated
2021-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

post-stroke cognitive impairment

Interventions

PSCI group:none
Non-PSCI group:none

Sponsors

Dongguan People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
45 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Aged 45 to 80 years; 2. Patients with acute ischemic stroke within 7 days of onset; 3. The first ischemic stroke; 4. NIHSS score <= 5 at admission and mRS < 2 at discharge; 5. There are complete clinical and imaging data, among which MRI of the brain needs to include T1WI, T2WI, DWI, FLAIR, SWI sequence; 6. The patient or family members signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. There is a clear cognitive impairment before admission, including Alzheimer's disease, frontotemporal degeneration, mental diseases and other diseases that affect cognitive function; 2. Cerebral hemorrhage, space-occupying lesions and other brain parenchymal diseases; 3. Obvious language and limb dysfunction left after cerebral infarction (mRS >= 3), unable to complete the cognitive function evaluation; 4. Severe visual and hearing impairment, unable to complete the cognitive function evaluation; 5. The presence of serious other systemic diseases at the time of admission, such as acute coronary syndrome, malignant tumors, alternative renal dialysis treatment, etc.

Design outcomes

Primary

MeasureTime frame
Montreal Cognitive Assessment Scale;

Countries

China

Contacts

Public ContactShi Zhu

Dongguan People's Hospital

sound_shi@126.com+86 769 22679351

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 6, 2026