Primary aldosteronism
Conditions
Interventions
Gold Standard:Normal saline test, captopril inhibition test, adrenal blood collection
Index test:Inhibition 
test 
of 
dexamethasone 
valsartan
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with persistent hypertension (>150/100mmHg, 1mmHg=0.133kPs); Patients whose blood pressure (>140/90mmHg) cannot be controlled with 3 conventional antihypertensive drugs (including diuretics); Patients with blood pressure (= 4 antihypertensive drugs and newly diagnosed hypertension patients. 2. Patients with hypertension complicated with spontaneous or diuretic hypokalemia. 3. Patients with hypertension complicated with adrenal accidental tumor. 4. Family history of early onset hypertension or early onset (<40 years old) hypertensive patients with a family history of cerebrovascular accident. 5. First-degree relatives with hypertension in patients with PHA. 6. Patients with hypertension complicated with obstructive sleep apnea.
Exclusion criteria
Exclusion criteria: 1. Complicated pregnant and lactating women, taking estrogen or oral contraceptives; 2. Complicated with severe heart (grade III or above), lung, liver, kidney (eGFR<30ml/min/1.73m2) and other diseases; 3. Patients with secondary hypertension whose etiology has been identified, such as: Cushing syndrome, subclinical Cushing syndrome, pheochromocytoma, renal artery stenosis, etc; 4. Patients who cannot tolerate ACEI; 5. Patients with clear use of non-antihypertensive drugs affecting RAAS results: such as licorice, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Plasma aldosterone concentration;Plasma renin concentration;Adrenocorticotropic hormone;Blood cortisol; | — |
Countries
China
Contacts
Public ContactChen Tao
West China Hospital of Sichuan University
Outcome results
None listed