Vascular associated overgrowth syndrome of extermities
Conditions
Interventions
The experimental group:Rapamycin given
Sponsors
Beijing Jishuitan Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 60 Years
Inclusion criteria
Inclusion criteria: 1. Clinically diagnosed as vascular-related overgrowth syndrome; 2. There is no restriction on gender and age; 3. No liver and kidney failure; 4. Volunteer to participate in the trial, and signed an informed consent form by the person or legal guardian.
Exclusion criteria
Exclusion criteria: 1. Acute and chronic infections, such as fever, cough, sputum expectoration, diarrhea, vomiting, dysuria, urgency, frequent urination, skin abscess, etc., white blood cells are larger than the normal range, CRP, PCT, erythrocyte sedimentation rate are increased; 2. Neutrophils are lower than 1.0x10^9/L; 3. Allergic to rapamycin; 4. Pregnant and lactating women; 5. Metabolic disorders, such as electrolyte disorders, abnormal blood sugar, etc.; 6. Patients with lung transplantation; 7. Patients with severe hyperlipidemia; 8. Abusers of alcohol, drugs or drugs (for example, laxatives); 9. Patients who participate in another clinical trial that may affect the purpose of this research at the same time or within one month; 10. Have a history of using rapamycin in the past month; 11. Have a history of major surgery in the past 12 weeks, have received surgery, interventional treatment and other invasive operations within 1 month, or have unhealed wounds, etc.; Have a history of live vaccination before 4 weeks; 13. Researchers believe that other reasons are not suitable for clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tissue volume of the affected site; | — |
Secondary
| Measure | Time frame |
|---|---|
| Steady-state plasma concentration of rapamycin;Blood biochemistry index;Blood coagulation function; | — |
Countries
China
Contacts
Public ContactTian Wen
Beijing Jishuitan Hospital
Outcome results
None listed