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Intraoperative intravesical Perfusion chemotherapy to Reduce bladder recurrence of upper tract Urothelial carcinoma following radical nephroureterectomy: a randomized controlled trial

Intraoperative intravesical perfusion chemotherapy to reduce bladder recurrence of upper tract urothelial carcinoma following radical nephroureterectomy: a randomized controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100045826
Enrollment
Unknown
Registered
2021-04-25
Start date
2021-05-01
Completion date
Unknown
Last updated
2021-12-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

upper urinary tract urothelial carcinoma

Interventions

Experimental group:During radical surgery (intravesical instillation was performed during the handling of the renal dissection, and the installation was emptied before the distal ureteral-cyst sleeve
Controll group:No intravesical perfusion chemotherapy during and after radical surgery

Sponsors

Department of Urology, Peking University First Hospital, Peking University Institute of Urology, National Urological Male Genital Tumor Research Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Aged at least 18 years; 2. No gender limit; 3. After urinary cytology, cystoscopy and CT urography, patients who are clinically considering initial urothelial carcinoma of the upper urinary tract and who are planned to undergo radical renal and ureteral full-length resection; 4. The patient voluntarily participates and signs an informed consent form; 5. Easy to understand and judge the requirements of clinical research.

Exclusion criteria

Exclusion criteria: 1. Patients with a history of bladder tumors; 2. Patients with urothelial carcinoma of the upper urinary tract complicated with bladder tumors; 3. Patients suffering from bilateral upper urinary tract urothelial carcinoma; 4. Patients whose tumor invades nearby organs or reaches perirenal fat through the kidney; 5. According to the judgment of the investigator, there are other patients who are not suitable for clinical research.

Design outcomes

Primary

MeasureTime frame
Bladder Recurrence Free Survival (BRFS);

Secondary

MeasureTime frame
Recurrence-free survival;Tumor-specific survival rate;Event-free survival;

Countries

China

Contacts

Public ContactZhou Liqun

Peking University First Hospital

zhoulqmail@sina.com+86 10 83572211

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026