psoriasis
Conditions
Interventions
psoriasis with LTBI:IL-17 inhibitors
psoriasis without LTBI:IL-17 inhibitors
Sponsors
Pekin Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. Clinically diagnosed moderate to severe plaque psoriasis with or without psoriatic arthritis, or erythroderma-type psoriasis, or pustular psoriasis: moderate to severe plaque psoriasis is defined as involvement Body surface area (BSA) >= 10%, or psoriasis area and severity index (PSoriasis area and severity index, PASI) >= 10; erythroderma-type psoriasis is defined as BSA >= 80%; pus Blister psoriasis is defined as generalized pustular psoriasis, excluding palmoplantar pustulosis or continuous acrodermatitis; but moderate to severe plaque psoriasis with palmoplantar pustulosis or continuous limbs Patients with dermatitis can be included in this study; 3. Volunteer to participate in this study and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating women; 2.Active tuberculosis; 3.Crohn's disease or ulcerative colitis; 4.Allergic to active ingredients or any component of IL-17 inhibitors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of active tuberculosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| PASI 75/90/100 responses;drug survival;adverse events; | — |
Countries
China
Contacts
Public ContactHe Chunxia
Peking Union Medical College Hospital
Outcome results
None listed