Chronic Kidney Disease
Conditions
Interventions
control group:Basic treatment
Sponsors
Zhejiang Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the Western medicine CKD 3-4 diagnostic criteria; 2. Meet the standard of Qi deficiency and blood stasis syndrome in TCM; 3. Those who are 18 to 75 years old, have no gender limit, and have not yet received dialysis treatment; 4. After basic blood pressure reduction, blood pressure 100g/L, no serious acidosis occurred; 6.24h urine protein quantification (24hUpr) <= 2.5g (at least two consecutive determinations, take the average); 7. The primary disease is chronic glomerulonephritis, hypertension, diabetes, hepatitis B-related nephritis, etc., and the condition is stable; 8. The patient agrees to the treatment of this study, joins the chronic disease management, and signs an informed consent form; 9. No other drug test has been performed in the past 3 months or the effective drug wash-out period has passed.
Exclusion criteria
Exclusion criteria: 1. Being treated with hormones, non-steroidal anti-inflammatory drugs or immunosuppressive agents; 2. Severe arrhythmia, acute heart failure, myocardial infarction, acute stroke, unstable angina, NYHA classification IV (New York Heart Association Heart Function Classification Standard); 3. Patients with acute infectious diseases, surgery and traumatic stress; patients with chronic infectious diseases such as chronic hepatitis B active and prolonged, decompensated liver cirrhosis, or active tuberculosis; 4. Diseases that are accompanied by severe organ damage that affect the survival of patients, such as malignant tumors, HIV infection, etc.; 5. Patients with severe primary diseases such as cardiovascular, blood system, nervous system, digestive system, respiratory system, etc., and those with obvious bleeding tendency; 6. Complicated with hyperkalemia, heart failure and other life-threatening persons; 7. GFR fluctuation range >= 30% within 3 months before enrollment; 8. Severe allergies, allergic or intolerant to certain drugs known in the study; 9. Patients during pregnancy or lactation; 10. Those who have had a history of hemorrhage or blood transfusion in the past 3 months, and have signs of serious clinical infection or acidosis; 11. Patients who have a history of mental illness or communication and cognitive dysfunction and other poor compliance who cannot cooperate; 12. Non-yellow race.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glomerular filtration rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| protein-creatinine ratio;serum creatinine;blood urea nitrogen;end point events incidence;TCM syndrome integral; | — |
Countries
China
Contacts
Public ContactLu Keda
The First Affiliated Hospital of Zhejiang University of Chinese Medicine
Outcome results
None listed