Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
immunization group:immunization with inactivated SARS-CoV-2 vaccine
Sponsors
The Fifth mMedical Center, Chinese PLA General Hospital, Beijing, China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. The inclusion criteria were as follows: 80-100 convalescent COVID-19 patients with normal body temperature and negative SARS-CoV-2 RNA 1 week before vaccination, aged between 18 and 65 years and the ratio of male gender to female gender was about 1:1. 2. The serum of convalescent volunteers was collected and the titer of neutralizing antibody was determined. The volunteers with neutralizing antibody titer less than 1:96 were enrolled in booster immunization group.
Exclusion criteria
Exclusion criteria: Patients with chronic severe underlying diseases, or patients who do not understand or may not comply with the test requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| SARS-CoV-2 virus neutralizing antibody in serum;RBD antibody titer; | — |
Secondary
| Measure | Time frame |
|---|---|
| specific T cell immune response to virus antigens;changes in subsets of immune cells; | — |
Countries
China
Contacts
Public ContactJingmin Zhao
The Fifth Medical Center, Chinese PLA General Hospital
Outcome results
None listed