limb ischemia-reperfusion
Conditions
Interventions
control group:received an equal amount of 0.9% saline
dexmedetomidine group:prior to tourniquet inflation patients received a loading dose of dexmedetomidine (0.8µg/kg over 10 min), followed by continuous infusion of dexmedetomidine (0.5 µg/kg/h)until en
Sponsors
Tianjin Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. ASA grade 1-3, patients (20-75 years old) who undergo elective lower extremity surgery and require tourniquets during the operation; 2. There are no contraindications for intraspinal anesthesia, no chronic bronchitis, asthma, etc. The estimated tourniquet application time is 60-90 minutes.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of arrhythmia and heart failure, with abnormal liver and kidney function; 2. There is a history of hormone application one week before the operation, and the expected anesthesia time is less than 1 hour or more than 4 hours, with signs of acute infection, and a history of immune system, nervous system and mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor necrosis factor-a;Interleukin-6;Brain-derived neurotrophic factor(BDNF);Endothelin-1;Pigment epithelium-derived factor; | — |
Secondary
| Measure | Time frame |
|---|---|
| Nausea, vomiting and other; | — |
Countries
China
Contacts
Public ContactRen Wanlu
Tianjin Hospital
Outcome results
None listed