Helicobacter pylori infection
Conditions
Interventions
group A:amoxicillin (1000mg twice A day)+ clarithromycin (500mg twice A day)+ bismuth (220mg twice A day)+ esomeprazole (20mg twice A day) for 2 weeks
group B:Group B:amoxicillin (1000mg, 3 times a day) + vonoprazan (20mg , twice a day) for 1 weeks.
group C:amoxicillin (1000mg, 3 times a day) + vonoprazan (20mg , twice a day) for 10 days.
group D:amoxicillin (1000mg, 3 times a day) + vonoprazan (20mg , once a day) for 2 weeks.
group E:amoxicillin (1000mg, 3 times a day) + esomeprazole (40mg, twice a day) for 2 weeks.
group F:amoxicillin (1000mg, twice a day)+ clarithromycin (500mg, twice a day)+ bismuth (220mg, twice a day)+ vonoprazan (20mg, once a day) for 2 weeks.
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Adult patients, aged 18 to 70 years; 2.Patients who did not take antibiotics, bismuth and traditional Chinese medicine 4 weeks before treatment, and patients who took PPI, H2 receptor antagonists and other drugs 2 weeks before treatment; 3.Hp-positive was diagnosed by C13 or C14-urea breath test and rapid urease test 4.Informed and agreed to participate in the study, patients with complete medical records and follow-up records.
Exclusion criteria
Exclusion criteria: 1.With severe heart, lung, and kidney dysfunction and low immunity; 2.Patients with drug allergy contraindications; 3.Persons with mental illness or communication difficulties; 4.Pregnancy, lactation; 5.Patients with organic diseases such as gastrointestinal tumor and gastrointestinal hemorrhage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| adverse reaction;antibiotic resistance of Helicobacter pylori;flora;Degree of clinical symptom remission; | — |
Countries
China
Contacts
Public ContactLin Zhihui
Fujian Provincial Hospital
Outcome results
None listed