Safety and efficacy of tranexamic acid in internal fixation of pilon fractures: a prospective randomized controlled trial

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100045768

Enrollment

Unknown

Registered

2021-04-24

Start date

2021-05-01

Completion date

Unknown

Last updated

2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pilon fracture

Interventions

Tranexamic acid group:Use tranexamic acid

Blank control group:None

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1.Closed Pilon fractures; 2.Can tolerate anesthesia and surgery; 3.Willing to cooperate with surgery and regular follow-up.

Exclusion criteria

Exclusion criteria: 1.Patients with rheumatoid arthritis, mandatory spondylitis, uncontrolled gout and other endocrine and rheumatic immune system diseases; 2.Alcoholism and smoking; 3.Uncontrolled diabetes, Especially in patients with diabetic peripheral neuropathy; 4.Systemic or local infection; 5.Poor local soft tissue condition after previous ankle surgery.

Design outcomes

Primary

Measure	Time frame
Hematological index;Complications;Visual analog pain score;SF-36 score;Postoperative hospital stay;Blood transfusion rate and average volume of blood transfusion;Symptomatic VTE and symptomatic PE;Deep vein thrombosis (rate);Incidence of incision complications (rate);Prosthetic infection (rate);Postoperative ground loading time;Postoperative activity time;Fracture healing;	—

Countries

China

Contacts

Public ContactZhang Hui

West China Hospital, Sichuan University

caesarzh@163.com+86 18980601437

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026