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To evaluate the efficacy of EGFR, GLUT-1 and PD-L1 targeting probes in preoperative and intraoperative fluorescence imaging of oral squamous cell carcinoma

To evaluate the efficacy of EGFR, GLUT-1 and PD-L1 targeting probes in preoperative and intraoperative fluorescence imaging of oral squamous cell carcinoma

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100045738
Enrollment
Unknown
Registered
2021-04-23
Start date
2021-05-01
Completion date
Unknown
Last updated
2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

oral squamous cell carcinoma

Interventions

Sponsors

Institute of Automation, Chinese Academy of Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1.Patients aged 18-70 years; 2.Patients with oral squamous cell carcinoma suspected by clinical and conventional imaging diagnosis and surgical indications; 3.No history of severe allergy; 4.The patients voluntarily participated in the clinical experiment and signed informed consent with the consent of their guardians. They were able to follow up and had good compliance.

Exclusion criteria

Exclusion criteria: 1.People who have received oral surgery; 2.Have received radiotherapy or neoadjuvant chemotherapy for oral squamous cell carcinoma; 3.Patients with ICG allergy; 4.Participate in clinical trials of other drugs within three months; 5.Women in reproductive period who are breast-feeding or pregnant and do not have adequate contraception; 6.The investigator does not consider it appropriate to participate in this clinical trial.

Design outcomes

Primary

MeasureTime frame
Sensitivity;Specificity;

Countries

China

Contacts

Public ContactZhang Haizhong

Chinese PLA General Hospital

zhanghaizhong301@aliyun.com+86 13901104968

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 5, 2026