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Effect of early mechanical ventilation on expression of inflammatory factors and prognosis of patients with severe traumatic brain injury

Effect of early mechanical ventilation on expression of inflammatory factors and prognosis of patients with severe traumatic brain injury

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100045732
Enrollment
Unknown
Registered
2021-04-23
Start date
2021-05-01
Completion date
Unknown
Last updated
2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head trauma

Interventions

Mechanical ventilation group:Nil
Routine oxygen inhalation group:Nil

Sponsors

Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Have a clear history of craniocerebral injury, diagnosed by computed tomography (CT) after admission; 2.Be admitted for treatment within 12 hours after injury; 3.Glasgow coma scale (GCS) score on admission <=8 points and no respiratory failure; 4.All treatments and tests have signed informed consent.

Exclusion criteria

Exclusion criteria: 1.Intracranial tumors; 2.Major basic diseases (cerebral infarction, myocardial infarction, malignant tumors, chronic obstructive pulmonary disease, acute and chronic bronchitis, etc.); 3.With other injuries (multiple fractures throughout the body) , Vital organ damage, the patient has hemorrhagic shock on admission); 4.Major diseases associated with other systems.

Design outcomes

Primary

MeasureTime frame
Partial blood oxygen pressure;Oxygenation index;Tumor necrosis factor-a;Interleukin-6;Interleukin-10;

Countries

China

Contacts

Public ContactChen Qianyi

Xinhua Hospital Chongming Branch, Shanghai Jiao Tong University School of Medicine

chenqy0215@sohu.com+86 13764840149

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026