Endometrial Cancer
Conditions
Interventions
Gold Standard:The pelvic lymph nodes were removed systematically and each node was examined by routine pathology.
lymph 
biopsy. 
only.
Group 
biopy 
(SLNB) 
by 
nanoparticles 
Sponsors
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.18-70 years old; 2.Diagnosed as endometrial cancer by pathological biopsy under hysteroscope or diagnostic curettage; 3.Clinically diagnosed stage I endometrial cancer; 4.Systemic imaging (thoracoabdominal enhanced CT or PET-CT) was used to assess the absence of retroperitoneal lymphatic metastasis and distant metastasis; 5.With ECOG<=2 points, hysterectomy and pelvic and para-aortic lymph node resection could be tolerated; 6.Volunteer to participate in the study and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1.Endometrial cancer patients suspected of cervical invasion or extrauterine tumor invasion by gynecological examination and imaging; 2.Allergic constitution, allergic to iodine or ICG skin test is positive; 3.Patients who has received radiotherapy or chemotherapy before enrollment; 4.History of primary malignancy other than endometrial cancer; 5.Patients combined with severe medical and surgical diseases, are unable to tolerate surgery; 6.Patients considered unsuitable for inclusion by the researchers; 7.Obvious dysfunction or chronic disease of heart, liver and kidney, or history of other malignant tumors.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall sentinel node detection rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Bilateral sentinel node detection rate;The number of detected sentinel nodes;Location of sentinel node;Sensitivity of sentinel node biopsy;False negative rate of sentinel lymph node biopsy;Sentinel lymph node biopsy negative predictive value;Duration of operation;Intraoperative bleeding volume; | — |
Countries
China
Contacts
Public ContactLi Bin
National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed