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A medical records based study for gadobenate dimeglumine-enhanced magnetic resonance imaging from the hepatobiliary phase can predict prognosis in patients with hepatitis B virus-related acute-on-chronic liver failure

Gadobenate dimeglumine-enhanced magnetic resonance imaging from the hepatobiliary phase can predict prognosis in patients with hepatitis B virus-related acute-on-chronic liver failure

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100045713
Enrollment
Unknown
Registered
2021-04-23
Start date
2021-05-01
Completion date
Unknown
Last updated
2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

HBV-ACLF

Interventions

Hepatitis B-related chronic and acute liver failure group:none

Sponsors

Provincial Hospital Affiliated to Shandong University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
28 Years to 79 Years

Inclusion criteria

Inclusion criteria: 1. For patients who were diagnosed with HBV-ACLF in Shandong Provincial Hospital from 2010 to 2019, the diagnosis of HBV-ACLF complies with the guidelines of the Asia Pacific Association for Liver Research (APASL): a history of CHB with jaundice (serum bilirubin >=5mg/dL) and coagulation dysfunction [International Normalized Ratio (INR)>=1.5 or Prothrombin Activity (PTA)<40%]; 2.Complicated with ascites and/or encephalopathy within 2.4 weeks.

Exclusion criteria

Exclusion criteria: 1. No or missing Gd-BOPTA enhanced MRI data within 2 weeks after HBV-ACLF diagnosis; 2. Tumor patients; 3. Patients with biliary diseases; 4. Patients with renal impairment; 5. Patients with severe cardiopulmonary complications; 6. Patients who have received liver transplantation or liver and biliary tract surgery.

Design outcomes

Primary

MeasureTime frame
Relative enhancement value of liver parenchymal hepatobiliary stage;Relative enhancement value of biliary tract hepatobiliary stage;cumulative survival;

Countries

China

Contacts

Public ContactZhao Xinya

Provincial Hospital Affiliated to Shandong University

zhaoxinya2000@126.com+86 15168887805

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026