infantile spasms
Conditions
Interventions
experimental group:Use vitamin B1
control group:Vitamin B1 is not used
Sponsors
Faculty of Pediatrics, the first Medical Centre, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged 2 months-2 years; 2. Clinically diagnosed as infantile spasm by an expert in pediatric neurology; 3. Standard, sleep, long-range, or video EEG is interpreted by a neuro-electrophysiological expert, showing diffuse high-amplitude slow rhythm, extensive spikes and slow activity, localized, multifocal spikes and sharp waves of high arrhythmia (or Atypical height arrhythmia); 4. Anti-epileptic drugs were not adjusted within two weeks and the epilepsy condition was stable; 5. Are taking vigabatrin for more than 1 week; 6. There are abnormal changes of vigabatrin-associated brain abnormalities on MRI (defined as T2WI high signal in the thalamus, globus pallidus, brainstem, and cerebellar dentate nucleus, and diffusion imaging (DWI) high signal); 7. All parents or guardians of the enrolled patients signed an informed consent form.
Exclusion criteria
Exclusion criteria: 1. There are other serious diseases that are not suitable for participating in the treatment, such as acute or infectious diseases, such as sepsis, pneumonia, urinary tract infection, electrolyte disorders, etc.; 2. Vitamin B1 is being taken orally; 3. Suffer from metabolic diseases; 4. Are participating in other medical experiments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Scoring of abnormal signal area of vigabatrin-associated brain abnormalities on MRI;Seizure frequency;EEG score; | — |
Countries
China
Contacts
Public ContactZou Liping
Faculty of Pediatrics, the First Medical Centre, Chinese PLA General Hospital
Outcome results
None listed