Effect of preoperative pain sensitization on neurocognitive function of elderly patients during perioperative period and anesthesia management

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100045683

Enrollment

Unknown

Registered

2021-04-23

Start date

2021-04-23

Completion date

Unknown

Last updated

2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

perioperative neurocognitive function disorder

Interventions

control group (CSI score =40 points):Nil

Eligibility

Sex/Gender

All

Age

60 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. BMI18.5~24.0 kg/m2, no gender limit; 2. ASA classification I ~ III, aged 60 ~ 85 years.

Exclusion criteria

Exclusion criteria: 1. Past surgery and anesthesia recovery history; 2. Alcohol abusers; 3. Smokers; 4. Patients with obvious abnormal liver and kidney function; 5. Past history of severe cardiovascular and cerebrovascular diseases; 6. History of lung disease; 7. Patients with severe vision and hearing impairment; 8. Those who cannot communicate normally; 9. Delirium, dementia, Alzheimer's disease and Parkinson's disease; 10. Those who do not cooperate cannot complete the test.

Design outcomes

Primary

Measure	Time frame
Central Sensitization Inventory;Mini-Mental State Examination (MMSE);Montreal Cognitive Assessment (MoCA);Auditory-verbal learning test;Trail making test;Stroop color and word test; Digit symbol substitution test; digital clock drawing test; Glasgow Coma Scale (GCS);Confusion Assessment Method-Chinese Reversion (CAM-CR);Numerical Rating Scale (NRS); Visual analogue pain score;Pittsburgh Sleep Quality Index (PSQI);Hospital Anxiety and Depression Scale (HAD);Osteoarthritis Index Score; Patient Recovery Quality Score; Richmond Agitation Sedation Scale;Patient satisfaction score;The Pain Catastrophizing Scale;Occurrence of burst pain;Geriatric Depression Scale (GDS); Tinetti Gait and Balance Test Scale Score;Rehabilitation related indicators;	—

Measure

Time frame

Central Sensitization Inventory;Mini-Mental State Examination (MMSE);Montreal Cognitive Assessment (MoCA);Auditory-verbal learning test;Trail making test;Stroop color and word test; Digit symbol substitution test; digital clock drawing test; Glasgow Coma Scale (GCS);Confusion Assessment Method-Chinese Reversion (CAM-CR);Numerical Rating Scale (NRS); Visual analogue pain score;Pittsburgh Sleep Quality Index (PSQI);Hospital Anxiety and Depression Scale (HAD);Osteoarthritis Index Score; Patient Recovery Quality Score; Richmond Agitation Sedation Scale;Patient satisfaction score;The Pain Catastrophizing Scale;Occurrence of burst pain;Geriatric Depression Scale (GDS); Tinetti Gait and Balance Test Scale Score;Rehabilitation related indicators;

—

Secondary

Measure	Time frame
Blood inflammation related indicators;Blood immunology related indicators; Intestinal flora related indicators;	—

Countries

China

Contacts

Public ContactWang Qiujun

The Third Hospital of Hebei Medical University

13933178001@163.com+86 13933178001

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026