Endometrial cancer
Conditions
Interventions
Group one:Simultaneous radiotherapy and chemotherapy + adjuvant chemotherapy for 6 cycles
Group two:3 cycles of chemotherapy + concurrent radiotherapy and chemotherapy + 3 cycles of chemotherapy
Sponsors
Anhui Cancer Hospita
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Women between 18 and 70 years old; (1) Stage I endometrial cancer has the following high-risk factors: (any stage of serous adenocarcinoma, any stage of clear cell adenocarcinoma, grade 3 deep invasive endometrial carcinoma); (2) The pathological stage is stage II-III, any histological type; 2. Karnofsky score >= 70; ECOG score 0-2 points; 3. There is a possibility of follow-up; 4. The patient signs an informed consent form; 5. The patient shall not receive any definite pelvic history radiotherapy before; 6. The investigator assessed that it is suitable for accepting and tolerating radiotherapy and chemotherapy.
Exclusion criteria
Exclusion criteria: 1. Accompanied by severe active infection or severe heart, liver, kidney and hematopoietic system diseases; 2. Poor compliance; 3. The withdrawal time of other clinical trial drugs is less than 4 weeks; 4. History of other primary malignant tumors, except for the following conditions: malignant tumors that have been cured, and there is no known active disease >= 5 years before the first administration of IP, and the potential risk of recurrence is low.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;Disease-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| safety;Quality of Life; | — |
Countries
China
Contacts
Public ContactLiu Yunqin
Anhui Cancer Hospital
Outcome results
None listed