Canceled by the investigator. Clinical study of perioperative multimodal analgesia applied to patients undergoing orthopedic surgery

Effect of different anesthesia methods and multi-modal analgesia on early recovery of patients undergoing knee arthroscopy combined with high tibial osteotomy

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100045672

Enrollment

Unknown

Registered

2021-04-20

Start date

2021-04-21

Completion date

Unknown

Last updated

2024-08-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

SP+NB Group:Intraspinal anesthesia combined with nerve block

GA+NB Group:General anesthesia combined with nerve block

SP Group:Intraspinal anesthesia

GA Group:General anesthesia

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Elective initial unilateral knee arthroscopy diagnosis and treatment combined with high tibial osteotomy; 2. Patients with unilateral knee osteoarthritis; 3. Aged <= 85 years; 4. ASA classification I~III; 5. BMI18~25 kg/m^2; 6. There is no restriction on gender.

Exclusion criteria

Exclusion criteria: 1. Contraindications for intraspinal anesthesia; 2. Contraindications of spinal anesthesia; 3. Other bone diseases such as rheumatoid and gouty arthritis; 4. Lower limb neuropathy; 5. Thrombosis in lower limbs; 6. Those who are allergic to anesthetics; 7. Those who are allergic to amide drugs; 8. Past surgery and anesthesia recovery history; 9. Diabetes; 10. History of gastritis, gastric ulcer and stomach surgery; 11. Patients with obvious abnormal liver and kidney function; 12. Past history of severe cardiovascular and cerebrovascular diseases; 13. History of lung disease; 14. History of head trauma; 15. History of fractures; 16. Delirium, dementia, Alzheimer's disease and Parkinson's disease; 17. Alcohol abusers; 18. Smokers; 19. Patients with severe vision and hearing impairment; 20. Those who do not cooperate cannot complete the experiment.

Design outcomes

Primary

Measure	Time frame
VAS pain score;Occurrence of postoperative pain;PCIA first compression time after surgery;PCIA compressions within 48 postoperatively;Number of postoperative salvage analgesia;Postoperative PACU stay time;Time to get out of bed for the first time;Hospital stay;Thrombosis in the lower extremities;Tinetti Gait and Balance Test Scale Score;Satisfaction score;48 h postoperative recovery quality score;	—

Measure

Time frame

VAS pain score;Occurrence of postoperative pain;PCIA first compression time after surgery;PCIA compressions within 48 postoperatively;Number of postoperative salvage analgesia;Postoperative PACU stay time;Time to get out of bed for the first time;Hospital stay;Thrombosis in the lower extremities;Tinetti Gait and Balance Test Scale Score;Satisfaction score;48 h postoperative recovery quality score;

—

Secondary

Measure	Time frame
Sensory block;Motor block;Agitation score;Sleep quality score;Comfort score;Cognitive function;WOMAC Osteoarthritis Score;Hospital for Special Surgery, HSS;Inflammation related indicators;Cellular immunological indicators;Intestinal flora related indicators;Adverse anesthesia events;	—

Countries

China

Contacts

Public ContactWang Qiujun

the Third Hospital of Hebei Medical University

13933178001@163.com+86 13933178001

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026