Diabetes
Conditions
Interventions
Group 1-1:Lunch high monounsaturated fat diet
Group 2-1:Dinner high monounsaturated fat diet
Group 1-2:Lunch high polyunsaturated fat diet
Group 2-2:Dinner high polyunsaturated fat diet
Sponsors
Harbin Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 69 Years
Inclusion criteria
Inclusion criteria: 1. Fasting blood glucose level (FPG)100-126 mg/dL, or 2 hours postprandial blood glucose level (2hPBG)140-199 mg/dL; 2. Fatty acid profile change: saturation Fatty acids (SFA) percentage increase, and unsaturated fatty acids (UFA) percentage decrease.
Exclusion criteria
Exclusion criteria: 1. Divide SFA, MUFA, and PUFA percentage into quintiles, and exclude the lowest quintile of SFA percentage and the highest quintile of MUFA and PUFA percentage; 2. Fever, infectious disease, gastrointestinal disease; 3. Combined hepatobiliary disease, malignant tumor, endocrine diseases and other autoimmune diseases, combined with severe organ damage such as heart, liver, brain and kidney; 4. Patients taking antibiotics, probiotics or prebiotics, and blood lipid-regulating drugs within 4 weeks before enrollment; 5. Insufficient time cannot be guaranteed to participate in this project.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Oral Glucose Tolerance Test;Insulin sensitivity index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dynamic blood glucose monitor;HbA1c;C peptide;Blood lipids;Inflammation factors;Oxidative stress index;Adhesion factor;Vascular endothelial growth factor;Soluble thrombomodulin;Endothelin-1;Intestinal flora;Enterobacteria-host co-metabolite;Serum Transcriptome Sequencing;Serum proteomics;Serum metabolites non-targeted metabolomics;Targeted metabolomics;Liver function;Kidney function;Serum ions; | — |
Countries
China
Contacts
Public ContactLi Ying
Harbin Medical University
Outcome results
None listed