Postoperative Cognitive Dysfunction
Conditions
Interventions
Control group:Placebo capsules
Sponsors
The Third Hospital of Xiangya
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients will have elective hip or knee replacement surgery; 2. Aged 60-90 years, regardless gender and race; 3. Without immune system disease; 4. Without psychiatric diseases and neurodegenerative diseases 5. Agree to participate in the study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. The frequency of surgery is more than 1 times or need emergency surgery; 2. Preoperative coma, severe dementia, speech impairment, severe hearing or visual impairment, Parkinson's disease can not communicate; 3. Symptoms of intestinal obstruction or confirmed intestinal obstruction; requires a long time of total parenteral nutrition after surgery; 4. Antibiotics, probiotics, gastrointestinal motility drugs have been used within 10 days before admission; 5. With perioperative myocardial infarctions or cerebrovascular accidents 6. Postoperative hospital stay duration was less than 7 days 7. The attending physician or researcher believes there are other conditions that should not be included in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative cognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| The composition and change of fecal flora;Systemic inflammation level; | — |
Countries
China
Contacts
Public ContactLe Yuan
Xiangya Medical College, Central South University
Outcome results
None listed