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Effects and Mechanism of Transcranial Direct Current Stimulation on Cough Reflex and Urge-to-Cough

Effects and Mechanism of Transcranial Direct Current Stimulation on Cough Reflex and Urge-to-Cough

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100045618
Enrollment
Unknown
Registered
2021-04-19
Start date
2021-04-16
Completion date
Unknown
Last updated
2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

stroke

Interventions

healthy adults group:different stimulation modes of tDCS
stroke patients group:fixed mode tDCS

Sponsors

Beijing Friendship Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
65 Years to No maximum

Inclusion criteria

Inclusion criteria: 1. Healthy adults: (1) Non-smoking adult young healthy people; (2) Not taking any drugs regularly; (3) No history of respiratory and lung diseases; (4) No known neurological or psychiatric history; (5) Sign the informed consent form. 2. Patients with stroke: (1) Confirmed by head CT or MRI scan; (2) Age is greater than or equal to 65 years old; (3) First stroke; (4) Right-handed and stroke is located in the blood supply area of the left middle cerebral artery; (5) No history of respiratory and lung diseases; (6) No medical history related to mental illness; (7) Sign the informed consent form.

Exclusion criteria

Exclusion criteria: 1. Healthy adults: (1) Respiratory tract infection or seasonal allergies in the past 4 weeks; (2) During menstruation, pregnant or breastfeeding; (3) There are metal implants in the body; (4) Alcoholism or drug addicts; (5) Patients who are hypersensitive to the irritation site. 2. Patients with stroke: (1) Patients with severe cognitive impairment cannot cooperate to complete the cough reflex test; (2) Have used ACEI, bronchodilators, hormones, antihistamines and antitussives in the past 4 weeks; (3) There are metal implants in the body; (4) Alcoholism or drug addicts; (5) Patients who are hypersensitive to the irritation site.

Design outcomes

Secondary

MeasureTime frame
pulmonary function;Electroencephalography;

Primary

MeasureTime frame
cough reflex threshold;urge-to-cough;

Countries

China

Contacts

Public ContactGui Peijun

Beijing Friendship Hospital, Capital Medical University

guipeijun@hotmail.com+86 15810225892

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 12, 2026