Application and study of individualized lung protective ventilation strategy in perioperative period of elective craniocerebral surgery

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100045607

Enrollment

Unknown

Registered

2021-04-19

Start date

2020-01-01

Completion date

Unknown

Last updated

2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Brain tumors, cerebrovascular diseases,

Interventions

Group 1:Small tidal volume + individualized PEEP + lung reconstruction

Group 2:Traditional ventilation strategy

Group 3:Traditional lung protective ventilation strategy

Eligibility

Sex/Gender

All

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. ASA classification 1-3; 2. Aged 18 years or above; 3. Brain tumor, cerebral aneurysm, cerebrovascular malformation; 4. Operation time > 3 hours; 5. Body mass index 18 - 35 kg/m^2.

Exclusion criteria

Exclusion criteria: 1. Preoperative radiotherapy patients; 2. Combine ALI/ARDS; 3. Combined heart failure or suspected combined heart failure; 4. Received mechanical ventilation (including CPAP) within 15 days before surgery; 5. Combined with pneumothorax or bullae; 6. Moderate to severe liver and kidney dysfunction; 7. Combined COPD that requires oxygen therapy or CPAP; 8. Participating in other clinical intervention trials.

Design outcomes

Primary

Measure	Time frame
Postoperative pulmonary complications;	—

Secondary

Measure	Time frame
Interleukin 6;Interleukin 8;	—

Countries

China

Contacts

Public ContactWang Qianrong

Huzhou Central Hospital

wqr0101030@163.com+86 13867253800

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026