Efficacy of intra-articular injection of leukocyte-rich PRP and leukocyte-poor PRP in the treatment of knee osteoarthritis

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100045601

Enrollment

Unknown

Registered

2021-04-19

Start date

2021-04-16

Completion date

Unknown

Last updated

2021-12-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

knee osteoarthritis

Interventions

LR-PRP group:LR-PRP Intra-articular injection

LP-PRP group:LP-PRP Intra-articular injection

Eligibility

Sex/Gender

All

Age

38 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Adults between 38 and 75 years old. 2. In line with the diagnostic criteria for osteoarthritis established by the American Academy of Rheumatology in 2009, knee pain plus radiological evidence within the past month and at least one of the following: morning stiffness is less than 30 minutes; there is friction/sound when the knee is moving . 3. X-ray evidence of knee osteoarthritis is 1, 2, 3, or 4 points (keligren lawrence radiology score): 0 (normal) no abnormalities in the joints; 1 (suspected) joint space can be narrowed, there may be Osteophytes; 2 (mild) there are obvious osteophytes, and the joint space can be narrowed; 3 (moderate) moderate osteophytes, the joint space is narrowed obviously, with sclerotic changes; 4 (severe) a large number of osteophytes, the joints gap is significantly narrowed, severely hardened and deformed. 4. The hemoglobin concentration is higher than 11 g/dL, and the platelet count is higher than 150,000/uL.

Exclusion criteria

Exclusion criteria: 1. Acute, infectious diseases (including local skin infections) or other systemic diseases; 2. Knee joint function is affected by other neurological or musculoskeletal diseases, such as stroke, fracture and rheumatoid arthritis; 3. Pregnant or lactating women; 4. There are severe heart and lung diseases and severe liver and kidney insufficiency; 5. History of knee surgery, received intra-articular injection therapy in the past 6 months; 6. Combined with cognitive impairment or mental disorder, unable to cooperate with treatment or follow-up; 7. Severe varus deformity of the knee joint, with varus greater than 5 degree.

Design outcomes

Primary

Measure	Time frame
WOMAC scores;	—

Secondary

Measure	Time frame
Pain visual analog scale;International Knee Documentation Committee Knee Evaluation Form;	—

Countries

China

Contacts

Public ContactWu Shaoling

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

13660183777@126.com+86 13660183777

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026