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To analyze the related markers and metabolic pathways of anesthesia sensitivity to inhaled sevoflurane in obstetric patients under general anesthesia based on metabolomics

An observational clinical study using metabonomics to explore the mechanism of anesthetic sensitivity

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100045580
Enrollment
Unknown
Registered
2021-04-19
Start date
2021-04-19
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia

Interventions

Sponsors

West China Second University Hospital, Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1. ASA I-II, aged 18-45, 28 weeks of gestation or above;Single live births; 2. Informed consent has been signed; 3. No recent history of cold; 4. Patients without other cardiovascular and cerebrovascular diseases; 5. Patients without any rare diseases; 6. In patients with type 2 diabetes, if the blood glucose level was adjusted by oral administration or injection before surgery, the preoperative blood glucose value fluctuated between 3.61-6.05mmol/L and less than 7.77mmol/L 2 hours after meal.

Exclusion criteria

Exclusion criteria: 1. It cannot cooperate with the research for any reason or the researcher thinks it is not suitable to be included in this trial; 2. Have any of the following medical history and past history: (1) Severe acute or chronic liver disease supported by any of the following indicators: hepatic encephalopathy, varicose veins, hemorrhage, INR> 1.7 without anticoagulation therapy; (2) Patients with malignant tumors of the brain, thyroid, liver and gallbladder; (3) A history of surgery for malignant tumors of the brain, thyroid, liver and gallbladder, as well as a history of radiotherapy and chemotherapy; (4) Recent history of acute infection: history of systemic chronic diseases such as endocrine, metabolism, breathing and circulation; (5) Long-term application history of narcotic analgesics; (6) People with a history of mental illness or neurosis, alcoholism, heavy smoking, and abnormal blood-borne diseases. 3. Have any of the following symptoms or signs (1) Severe COPD or ischemia causes breathing difficulties; (2) Difficulty breathing caused by ischemia; (3) Blood pressure and heart rate meet one of the following: 1) SBP 180 mmHg; 2) DBP 100 mmHg; 3) Resting heart rate> 110 bpm; 4. Laboratory examination: hemoglobin is lower than 8.0 g/dl; 5. The imaging examination confirms that the ejection fraction is less than 45%; 6. Failure to comply with the planned research process.

Design outcomes

Primary

MeasureTime frame
Inhaled drug concentration during anaesthesia recovery;

Countries

China

Contacts

Public ContactLiu Hui

West China Second University Hospital, Sichuan University

liuhui_scu@163.com+86 28 85503753

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026