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Repetitive transcranial magnetic stimulation at different sites for non-fluent aphasia after stroke: a randomized, double-blind clinical trial

Repetitive transcranial magnetic stimulation at different sites for non-fluent aphasia after stroke: a randomized, double-blind clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100045565
Enrollment
Unknown
Registered
2021-04-19
Start date
2021-04-20
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neurological disease

Interventions

The unaffected group:High frequency repetitive transcranial magnetic stimulation of the left Broca area combined with traditional language training
The affected group:Low frequency repetitive transcranial magnetic stimulation of the right Broca area combined with traditional language training
The control group: Traditional language training

Sponsors

Yuebei People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. The diagnoses of stroke had been confirmed by brain CT or MRI, and the lesions were located within the left hemispheric Broca Area. 2. Meet the WAB non-fluency aphasia diagnostic criteria: aphasia <93.8 points, language fluency test 0-4 points. 3. The Severity of Aphasia Scale is assessed as a moderate to severe aphasia. 4. Patients with onset time of 1-12 weeks. 5. Patients younger than 80 years old and above elementary school education. 6. No history of epilepsy, severe heart disease or other serious physical diseases. 7. All patients are right-handed. 8. The patient and family members signed an informed consent form.

Exclusion criteria

Exclusion criteria: 1. Patients with unclear consciousness and serious cognitive impairment can not cooperate. 2. Past language barriers, and current stroke accompanied by severe dysarthria. 3. Language disorders caused by other neurodegenerative diseases. 4. There are contraindications to repeated transcranial magnetic stimulation, such as implantation of metal objects in the body, VP shunt in the brain, history of epilepsy, etc. 5. The patient and his family members do not receive treatment.

Design outcomes

Primary

MeasureTime frame
The Chinese version of the Western Aphasia Battery(WAB);

Countries

China

Contacts

Public ContactLiu Huiyu

Yuebei People's Hospital

liuhuiyudoctor@sohu.com+86 13922599818

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026