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Amino acid-based formula vs extensively hydrolyzed formula improves feeding intolerance in preterm infants: a randomized controlled trial

Amino acid-based formula vs extensively hydrolyzed formula improves feeding intolerance in preterm infants: a randomized controlled trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100045563
Enrollment
Unknown
Registered
2021-04-19
Start date
2021-04-19
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

feeding intolerance in preterm infants

Interventions

experiment group:amino acid-based formula
control group: extensively hydrolyzed formulas

Sponsors

Children's Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. The time of admission is from February 2021 to November 2022; 2. Eligible patients are infants with 28 weeks <= Gestational age <= 34 weeks, 840g <= birth weight <= 2000g, appropriate for gestational age, and are admitted to department of neonatology, Childrens Hospital of Chongqing Medical University within the first 24 h after birth; 3. Patients receive preterm formula after admission; 4. Meet the diagnostic criteria of feeding intolerance; 5. Written informed consent is obtained from guardians.

Exclusion criteria

Exclusion criteria: 1. Apgar score 40% (nasal intubation and/or nasal continuous positive airway pressure (CPAP) and/or oxygen mask are allowed); 6. Diagnosis of grade III or IV ventricular hemorrhage (IVH) before randomization or on the day of grouping.

Design outcomes

Primary

MeasureTime frame
Duration of whole intestinal feeding;—

Countries

China

Contacts

Public ContactLu Qi

Children's Hospital of Chongqing Medical University

qilu_qi@163.com+86 15823020185

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026