Research on the effect of extracellular vesicles (EV) in follicular fluid on the function of granulosa cells

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2100045531

Enrollment

Unknown

Registered

2021-04-18

Start date

2021-04-17

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility

Interventions

Non-elderly ovaries function normally group:None

Ovarian function declines in non-advanced age group:None

Ovaries function normally in advanced age group:None

Ovarian reserve declines in advanced age group:None

Eligibility

Sex/Gender

Female

Age

18 Years to 45 Years

Inclusion criteria

Inclusion criteria: 1.The first/second IVF/ICSI cycle; 2.Age 18-45; 3.No abnormalities of the uterine cavity or endometrium (uterine fibroids, endometrial polyps, malformations, adenomyomas, endometritis , Intima is thin); 4.There is no hydrosalpinx; 5.There is no risk of infection; 6.Fresh autologous embryo transfer, no PGD or testicular biopsy.

Exclusion criteria

Exclusion criteria: Polycystic ovary syndrome, endometriosis, abnormal thyroid function, other endocrine and immune system diseases.

Design outcomes

Primary

Measure	Time frame
Follicular fluid exosomes micRNA;Expression of protein;Granulosa cell apoptosis;	—

Countries

China

Contacts

Public ContactWang Yanbin

Peking University People’s Hospital

iriswang411@163.com+86 18611800160

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 14, 2026