chronic obstructive pulmonary disease, COPD
Conditions
Interventions
Acute stage experimental group:Calcitriol capsule 0.25ug/ time, once/day combined with conventional treatment
Acute stage control group:Placebo combined with conventional treatment
Stable period experimental group:Calcitriol capsule 0.25ug/ time, once/day combined with conventional treatment
Stable period control group:Placebo combined with conventional treatment
Sponsors
Chongqing Occupational Disease Prevention and Treatment Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients clinically diagnosed as acute phase and stable phase with moderate to severe COPD should meet the diagnostic criteria of the Gold Guidelines for the Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease (revised 2019); 2.Serum 25(OH)D level less than 25 nmol/L.
Exclusion criteria
Exclusion criteria: 1.Patients with severe cardiovascular and cerebrovascular diseases, pulmonary interstitial diseases, bronchial asthma; 2.Recent oral history of vitamin D, contraindications to taking vitamin D (such as hypervitamin D, hypercalcemia, hyperphosphatemia with renal rickets); 3.Mental disorders who are unable to cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum levels of interleukin 27; | — |
Secondary
| Measure | Time frame |
|---|---|
| Remission rate;CD4 cell count;Serum 25 (OH) D level;Percentage of forced expiratory volume in first second to estimated value;Percentage of forced expiratory volume in first second in forced expiratory volume; | — |
Countries
China
Contacts
Public ContactWang Dongmei
Chongqing Occupational Disease Prevention and Treatment Hospital
Outcome results
None listed