Postpartum depression
Conditions
Interventions
Es-ketamine group:After the block level is stabilized, a single dose of esketamine 0.15 mg/kg is applied intravenously before skin incision
Control group:After the block level is stabilized, an equal volume of normal saline is injected intravenously before skin incision
Sponsors
The First Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
Female
Age
21 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Aged 21 to 35 years old, ASA I-II level with term singleton pregnancy. 2. No circulatory, respiratory, endocrine, and blood system disease; 3. No contraindications to intraspinal anesthesia, no and normal preoperative monitoring of fetal heart rate; 4. Plan to perform elective cesarean delivery; 5. Agree to participate in the study and sign the informed consent form for clinical research.
Exclusion criteria
Exclusion criteria: 1. Previous history of mental illness, use of psychotropic drugs, neurological diseases such as epilepsy, and suicidal intention or suicide; 2. History of drug, alcohol, or opioid abuse; 3. Application of monoamine oxidase inhibitor treatment within 14 days; 4. Participate in other clinical studies; 5. Suffering from severe heart disease, cerebral disease, liver disease or kidney disease; 6. Allergy to esketamine or any contraindications to combined spinal-epidural anesthesia; 7. With serious pregnancy complications: high blood pressure, eclampsia and preeclampsia; 8. Illiteracy, language disability, or communication difficulty due to hearing or vision impairment; 9. Parturient with full stomach.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| EPDS(Edinburgh Postnatal Depression Scale); | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS (visual analog scale);Related complications;Vital signs and Apgar score;interleukin-2;interleukin-4;interleukin-6;interleukin-10;tumor necrosis factor-alpha;interferon-gama; | — |
Countries
China
Contacts
Public ContactJi Fuhai
The First Affiliated Hospital of Soochow University
Outcome results
None listed