The comparison of hemodynamic effects in the anesthesia induction between remimazolam and midazolam for elderly patients underwent non-cardiac surgery: a prospective, random, control study

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100045491

Enrollment

Unknown

Registered

2021-04-17

Start date

2021-06-01

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hemodynamic fluctuation during induction of general anesthesia

Interventions

Remimazolam Group:Remimazolam 0. 05 mg /kg i.v.

Midazolam Group:Midazolam 0. 05 mg /kg i.v.

Eligibility

Sex/Gender

All

Age

60 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. The patients and their legal representatives voluntarily participated in the study and signed the informed consent; 2. Hospitalized in our hospital and underwent elective noncardiac surgery; 3. Over 60 years old, regardless of gender; 4. No sedative drugs were taken before operation.

Exclusion criteria

Exclusion criteria: 1. Combined with important organ dysfunction: including severe liver and kidney dysfunction, brain organic diseases, NYHA >= grade III, coagulation dysfunction, sick sinus syndrome, degree II or above atrioventricular block; 2. Contraindications for the use of remimazolam; 3. Patients considered unsuitable by other researchers.

Design outcomes

Primary

Measure	Time frame
Incidence of patients with MAP < 60mmHg;	—

Secondary

Measure	Time frame
Total dose of propofol;Ramsay score;	—

Countries

China

Contacts

Public ContactLi Xiang

The Third Affiliated Hospital, Sun Yat-Sen University

lixiang27@mail.sysu.edu.cn+86 15602391780

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026