blood protection
Conditions
Interventions
Group A:tranexamic acid low-dose group, 0.5g tranexamic acid intravenous drip before skin incision + 0.5g tranexamic acid intravenous drip after prosthesis installation
Group B: tranexamic acid high-dose group, 1 g tranexamic acid intravenous drip before skin incision + 1 g tranexamic acid intravenous drip after prosthesis installation
group C:control group, 100 ml normal saline intravenous drip before skin incision + 100 ml normal saline intravenous drip after prosthesis installation
group D:tranexamic acid pump group, 1 g tranexamic acid intravenous drip before skin incision + 0.5 g / h tranexamic acid continuous pump for 2 hours
Sponsors
The First People's Hospital of Nanning
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >=18 years, ASA classification II~IV; 2. Patients who intend to undergo total hip replacement surgery under intraspinal anesthesia; 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Re-operation of the hip joint; 2. Those who are allergic to tranexamic acid ingredients; 3. Patients with thrombosis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the amount of blood loss (intraoperative blood loss + drainage volume 48 hours after operation);the amount of blood transfusion;Thromboelastogram;coagulation function;routine blood test; | — |
Secondary
| Measure | Time frame |
|---|---|
| Ultrasound examination of lower extremity vessels;renal dysfunction;thromboembolism;epilepsy;death; | — |
Countries
China
Contacts
Public ContactDeng Jicai
The First People's Hospital of Nanning
Outcome results
None listed