Gastrointestinal function
Conditions
Interventions
butorphanol group:Use butorphanol for analgesia
fentanyl group:Use fentanyl for analgesia
Sponsors
The First Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Non-abdominal surgery patients requiring mechanical ventilation and ICU monitoring after surgery. 2.Aged > 18 and <= 80 years, no gender limitation; 3.The expected treatment time in ICU is less than 48h; 4.Voluntarily sign the informed consent and participate in the study.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to opioids; 2. Patients with gastrointestinal ischemia and other diseases; 3. People with mental illness; 4. Long-term use of opioids in the past for more than 2 weeks (oral or intravenous, analgesic patch), drug addiction; 5. Liver and kidney dysfunction (liver enzymes greater than 3 times the normal value or child score above B grade; creatinine clearance rate < 50ml/min); 6. Patients with bradycardia (heart rate <= 50 beats/min), third degree atrioventricular block, systolic blood pressure <= 90 mmHg; 7. Pregnant or lactating women; 8. Patients with persistent epilepsy; 9. Patients with severe gastrointestinal dysfunction; 10. Patients who are expected to die within 48 hours; 11. Participate in other clinical trials within 30 days before enrollment; 12. The investigator believes that it is not suitable to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gastrointestinal function recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| analgesic effect; | — |
Countries
China
Contacts
Public ContactChen Minying
Department of Surgical Intensive Care Unit, The First Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed