Application of high frequency oscillatory ventilation in premature infants

Noninvasive high-frequency oscillatory ventilation versus bi-level positive pressure ventilation in premature infants with respiratory failure: a randomized controlled study

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100045446

Enrollment

Unknown

Registered

2021-04-15

Start date

2021-05-14

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

respiratory failure in premature infants

Interventions

nHFOV group:Use nHFOV breathing mode for breathing support

Bipap group:Use Bipap breathing mode for breathing support

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. 25 weeks <= gestational age <= 34 weeks; 2. Patients with neonatal respiratory failure diagnosed within 1 hour after birth and requiring noninvasive assisted ventilation.

Exclusion criteria

Exclusion criteria: 1. Severe asphyxia (1 minute Apgar < 4 at 1minutes, or cord blood pH <7.0); 2. Cyanotic congenital heart disease (cCHD); 3. Maxillofacial developmental abnormalities (cleft palate, Distorted nasal septum, atresia of posterior foramen); 4. Chromosomal disease, genetic metabolic disease; 5. Shock; 6. Give up treatment within seven days of admission; 7. Infants who needed tracheal intubation and mechanical ventilation within 1 hour after birth.

Design outcomes

Primary

Measure	Time frame
Mechanical ventilation rate required for endotracheal intubation;	—

Secondary

Measure	Time frame
Changes of pCO2 before and after ventilation;Oxygenation index;SpO2 distribution;Bronchopulmonary dysplasia (BPD);	—

Countries

China

Contacts

Public ContactChen Wenqian

Fujian Maternity and Child Health Hospital

chwenqian@163.com+86 18960938870

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026