Effect of preoperative intranasal esmketamine on preoperative separation and sevoflurane anesthesia induction in preschool children undergoing strabismus surgery

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100045441

Enrollment

Unknown

Registered

2021-04-15

Start date

2021-10-01

Completion date

Unknown

Last updated

2022-04-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preoperative sedation in preschool children

Interventions

EK1 group:0.5mg/kg intranasal esmketamine

EK2 group:1mg/kg intranasal esmketamine

Eligibility

Sex/Gender

All

Age

3 Years to 6 Years

Inclusion criteria

Inclusion criteria: 1. Aged 2-5 years, no gender limit; 2. Weight 10-25kg, ASA I-II; 3. No history of heart or lung disease; 4. Children undergoing elective strabismus surgery.

Exclusion criteria

Exclusion criteria: 1. Children with recent upper respiratory tract infection or obvious rhinitis and runny nose; 2. Specific mental illness, severe central system disease or increased intracranial pressure; 3. Allergic to esketamine or the parents refuse to use the preoperative medication.

Design outcomes

Primary

Measure	Time frame
Preoperative separation score;Sevoflurane anesthesia induction cooperation;	—

Secondary

Measure	Time frame
Adverse reactions;Pulse oxygen saturation;Heart rate;Ramsay Sedation score;Induction time of sevoflurane;emergence agitation;	—

Countries

China

Contacts

Public ContactSun Ruiqiang

Tianjin Eye Hospital

1043203628@qq.com+86 18602643440

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026