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Comparison of Esketamine and Dexmedetomidine in Reducing Agitation after Tonsillectomy in Children

Comparison of Esketamine and Dexmedetomidine in Reducing Agitation after Tonsillectomy in Children

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2100045409
Enrollment
Unknown
Registered
2021-04-14
Start date
2021-05-01
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Obstructive Sleep Apnea Hypopnea Syndrome

Interventions

Group D:Esketamine 0.25mg/kg
Group E:Dexmedetomidine 0.5ug/kg

Sponsors

Department of Anesthesiology, Shenzhen Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
3 Years to 7 Years

Inclusion criteria

Inclusion criteria: 1. Aged 3-7 years, no gender limits; 2. Weight 10-25 kg; 3. ASA I-II; 4. No history of heart or lung disease; 5. No abnormalities in liver and kidney function; 6. The children and their families cooperate well.

Exclusion criteria

Exclusion criteria: 1. Patients at serious risk of increased blood pressure or intracranial pressure; 2. Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic/diastolic blood pressure exceeding 180/100mmHg); 3. Untreated or undertreated patients with hyperthyroidism; 4. Children with autism; 5. Patients with heart block; 6. People with cardiac insufficiency.

Design outcomes

Primary

MeasureTime frame
Pediatric Anesthesia Behavior;Pediatric Anesthesia Emergence Delirium score;Ramsay sedation score;Visual Analogue scale;

Secondary

MeasureTime frame
Extubation time (the time from drug withdrawal to removal of the tracheal tube);Post-Anesthesia Care Unit stay time;

Countries

China

Contacts

Public ContactMa Xingang

Shenzhen Children's Hospital

gdszmxg@126.com+86 18938690935

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026