The changes of clinical symptoms and intestinal flora of patients with Parkinson's disease before and after ketogenic diet and the control study of the flora of normal healthy population

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2100045394

Enrollment

Unknown

Registered

2021-04-14

Start date

2021-04-15

Completion date

Unknown

Last updated

2021-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson's disease

Interventions

PD group:ketogenic diet

Healthy control group:Not stated

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. According to the clinical diagnostic criteria of PD published by the Movement Disorders Association in 2015, clinically confirmed patients with primary Parkinson's disease; 2. No digestive system diseases, such as inflammatory enteritis, liver, gallbladder and pancreatic diseases; No digestive system stones and surgery; 3. Not taking any antibiotics in the last 3 months; 4. No diabetes and autoimmune diseases; 5. No familial aggregation of Parkinson's disease.

Exclusion criteria

Exclusion criteria: 1. Parkinson's superimposed syndrome; 2. Drugs and medicines: any drugs and medicines abuse, any regular use of the following medicines in the past 2 months (> 2 times): opioids, lopebutamine, inhaled beta-blockers or anticholinergics, glucocorticoids (oral or extraenteral), tricyclic antidepressants, antihistamines and anticholinergics (except for signs of PD), metoclopramide, cholinergics, doperidone, and proton pump inhibitors; 3. Organ failure: heart failure (excluding: cardiac function grade <= 2), known severe renal insufficiency (glomerular filtration rate < 30ml/min); 4. Other: B vitamin deficiency, serious uterine prolapse, peritonitis, the history of severe endometriosis, polyneuropathy, polio, symptomatic peripheral atherosclerosis (e.g. claudication), aortic aneurysm or dissection, lungs, or skin cancer, stomach, intestines, or urogenital fistula, any of the following happened 2 month before : one of severe hypokalemia or hyperkalemia requiring hospitalization, coma or gastrointestinal endoscopy, abdominal trauma.

Design outcomes

Primary

Measure	Time frame
Parkinson's disease related scale;Changes in intestinal flora;Changes in inflammatory cytokines;	—

Countries

China

Contacts

Public ContactChi Chunling

The Fourth Affiliated Hospital of Harbin Medical University

2532353212@163.com+86 15124528409

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026