Suboptimal health
Conditions
Interventions
experimental group:Two weeks of low-gluten intake
four weeks of high-gluten intake
and two weeks of low-gluten intake, in that specific order.
Sponsors
Affiliated Hospital of Jiangnan University
Eligibility
Sex/Gender
All
Age
19 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. In good health (no chronic disease, no antibiotics used in the last 3 months); 2. The daily habit is to take rice as the staple food, and eat less wheat-based products; 3. Aged > 18 years; 4. Subjects fill in written informed consent and questionnaire, and promise to cooperate throughout the study period.
Exclusion criteria
Exclusion criteria: 1. Gluten intolerance; 2. Suffer from chronic diseases or any other abnormal physical condition or medical condition affecting the gastrointestinal tract; 3. Use drugs related to digestive tract disease within two weeks, such as anti-spasmodic, laxative, anti-diarrhea drugs, etc.; 4. Use antibiotics in the last 3 months; 5. Pregnancy or lactation; 6. A history of convulsive symptoms or mental illness; 7. Significant changes in dietary habits occurred in the last 1 month; 8. Currently participating in, or have participated in any other clinical studies within the past month.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Salivary metagenomics;Fecal metagenomics;Gut permeability;Breath gas;Serum metabolomics; | — |
Secondary
| Measure | Time frame |
|---|---|
| Height;Weight;Body fat percentage;Skeletal muscle mass;Complete blood count;Liver function tests;Renal function tests;Blood lipids;Urinalysis;Heart rate;Systolic blood pressure;Diastolic blood pressure;Blood glucose;Stool pH;Bristol stool scale; | — |
Countries
China
Contacts
Public ContactZhang Feng
Affiliated Hospital of Jiangnan University
Outcome results
None listed