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Characterization investigation of gut microbiota and metabolites in gestational diabetic mellitus patients in the prenatal and postnatal periods based on multi-omics techniques

Characterization investigation of gut microbiota and metabolites in gestational diabetic mellitus patients in the prenatal and postnatal periods based on multi-omics techniques

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2100045368
Enrollment
Unknown
Registered
2021-04-13
Start date
2021-06-01
Completion date
Unknown
Last updated
2021-11-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational diabetes mellitus

Interventions

Normal group:Nil

Sponsors

Xinhua Hospital, Shanghai Jiaotong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: GDM case group: according to the industry standard of the People's Republic of China, which is derived from the Guidelines for the diagnosis and management of gestational diabetes (2014). Pregnant women were screened for gestational diabetes at 24-28 weeks of gestation using a 75g oral glucose tolerance test (OGTT) with the following diagnostic cut-off values for OGTT: fasting, 1-hour, and 2-hour glucose values of 5.1 mmol/L, 10.0 mmol/L, and 8.5 mmol/L, respectively. If any of the blood glucose values meet or exceed these thresholds, GDM is diagnosed. Pregnant women diagnosed with GDM were not treated with insulin. Control group: The control group was a 1:1 matched case group with normal blood glucose screening test.

Exclusion criteria

Exclusion criteria: 1.History of significant organ disease; 2.History of infectious disease or infection during pregnancy; 3.Use or ongoing use of drugs that interfere with choline metabolism during pregnancy.

Design outcomes

Primary

MeasureTime frame
Gut microbial compositions;Meals;

Secondary

MeasureTime frame
Body weight and height;

Countries

China

Contacts

Public ContactJia Jie

Shanghai Jiaotong University School of Medicine

jie.jia@shsmu.edu.cn+86 13122322289

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026