Depression
Conditions
Interventions
Treatment group:Implantable deep brain stimulation system
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18-70 years, regardless of gender; 2.Psychiatrist diagnosed major depressive disorder according to Diagnostic And Statistical Manual Of Mental Disorders. 5th Ed (DSM-V); 3.Psychiatric examination by two trained psychiatrists and diagnosis according to DSM-V, diagnosis consistent; 4.A history of depression lasting at least 24 months, with a reduction rate of = 20; 6.Global Assessment Function(GAF) score <= 50; 7.Patient or legal guardian need fully understand the treatments and sign the informed consent before Adding to the group.
Exclusion criteria
Exclusion criteria: 1.Patients with severe or unstable heart, liver, kidney, endocrine, blood and other internal diseases or comorbidities with psychotic symptoms, including the personality disorders diagnosed during medical history, consultation and clinical examination; 2.Patients with a history of drug abuse within 12 months; A history of epilepsy, or high fever and convulsion in childhood; 3.Subjects who had attempted suicide in the past 6 months or more than 2 suicide attempts in the past 2 years; 4.Women who are breast-feeding, pregnant, and subjects who are pregnant or planning to become pregnant during the clinical study; 5.Patients have contraindications about DBS surgery and chronic irritation; 6.Subjects of involuntary hospitalization.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subtraction rate of Hamilton scale; | — |
Countries
China
Contacts
Public ContactCui Zhiqiang
Chinese PLA General Hospital
Outcome results
None listed