Remifentanil-induced hyperalgesia
Conditions
Interventions
Control group:Normal saline
Flurbiprofen group:Flurbiprofen
Flurbiprofen combined with Nalbuphine group:Flurbiprofen combined with Nalbuphine
Sponsors
Department of Anesthesiology, Wuhu Second Peoples Hospital, Anhui
Eligibility
Sex/Gender
All
Age
20 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.ASA I-II objects; 2.Subjects aged 20-65 years old; 3.18 <= BMI <= 29.
Exclusion criteria
Exclusion criteria: 1.Patients who are allergic to experimental drugs or have other contraindications; 2.With serious heart,lung, liver, kidney and brain diseases; 3.Severe blood system dysfunction; 4.Peptic ulcer active stage; 5.Patients with history of mental disorders, chronic pain, or abnormal pain perception; 6.Recent history of pain, including surgery and trauma; 7.Long-term use of sedative analgesics or dependence on sedative analgesics patients, alcoholism patients; 8.Pregnant and lactating women; 9.For other reasons, they were not considered suitable subjects for study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain threshold; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numerical grading of pain score;Blood pressure and heart rate at each intraoperative time point;Ramsay sedation score;Operative anesthesia time;Awakening time;Intraoperative dosage of remifentanil;Additional analgesic drugs after operation; | — |
Countries
China
Contacts
Public ContactLu Yao
Department of anesthesiology, Wuhu Second Peoples Hospital
Outcome results
None listed