cough
Conditions
Interventions
Dexmedetomidine group:Intravenous injection 0.5 ug/kg
Control group:Equal dose of saline solution
Sponsors
The First Affiliated Hospital of the Air Force Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Patients scheduled for neurosurgery under general anesthesia with Tracheal intubation from April 2021; 2.American Society of Anesthesiologists Asa Rating: I~III; 3.Age 18-70; 4.No aural, speech, visual, and hearing impairment, fully conscious and able to cooperate; 5.Signed informed consent form.
Exclusion criteria
Exclusion criteria: 1.A history of upper respiratory tract infection within 2 weeks; 2.A previous history of chronic lung disease or asthma; 3.A contraindication to Dexmedetomidine such as Anaphylaxis, Sinus Bradycardia, and Heart Block; 4.A post-operative plan to take a tracheal catheter to the Intensive Care Unit; 5.Participation in this or other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of cough during resuscitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate, blood pressure, cough severity, extubation time, sinus bradycardia, post-operative hypoxia, respiratory depression, laryngeal spasm, bronchospasm, secondary intubation and other adverse events were assessed and recorded;Ricker sedative-agitation score during resuscitation;Visual analogue scale;Postoperative nausea and vomiting score; | — |
Countries
China
Contacts
Public ContactZhang Haopeng
The First Affiliated Hospital of the Air Force Medical University
Outcome results
None listed