gastroscopy in obese patients
Conditions
Interventions
Experience group:S-k group (esketamine group) : oral and pharyngeal surface anesthesia was performed with dacronine gum slurry. Then propofol 1.5mg/kg (fat removal weight) was slowly injected for 1min
Control group:R group (remifentanil group) : patients in both groups received oral and pharyngeal surface anesthesia with dacronine gum slurry. Then propofol 1.5mg/kg (fat removal weight) was slowly i
Sponsors
Department of Anesthesiology, Beijing Tsinghua Changgung Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1.ASAI-III, patients undergoing painless gastroscopy; 2.Aged 18-50 years, BMI: 30-45 kg/m^2, systolic pressure 90-140mmhg, diastolic pressure 50-90mmhg, resting heart rate 50-100bpm, SpO2 >= 95% (no oxygen inhalation); 3.Malampati airway classification 80%.
Exclusion criteria
Exclusion criteria: 1.Patients refused to be included; 2.Allergic to the drugs (active ingredients or all excipients) used in this study; 3.He has epilepsy and other mental diseases, and has a history of addiction to analgesics such as opium and / or sedatives (sleeping pills); 4.Patients with severe risk of elevated blood pressure or intracranial pressure, poorly controlled or untreated hypertension (arterial hypertension, resting blood pressure >= 180 / 100mmhg); 5.Preeclampsia or eclampsia; 6.Hyperthyroidism without treatment or insufficient treatment; 7.Severe cardiac dysfunction: Patients with NYHA cardiac function grade 3-4, recent myocardial infarction or cerebral infarction, severe conduction block or malignant arrhythmia; 8.Renal failure (decreased glomerular filtration rate (GFR), endogenous creatinine clearance rate (Ccr) > 50mL / min; serum creatinine (Scr) 3) or persistent state of asthma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of respiratory related adverse events requiring human intervention;Respiratory related adverse events; | — |
Secondary
| Measure | Time frame |
|---|---|
| modified observer’s assessment of alert /sedation, MOAA/S;Pain; | — |
Countries
China
Contacts
Public ContactZhang Huan
Department of Anesthesiology, Beijing Tsinghua Changgung Hospital
Outcome results
None listed